Do you charge sales tax on items shipped out-of-state?

Whether you charge sales tax on items shipped out of state depends on your nexus status in the destination state. Post-South Dakota v. Wayfair (2018), most states have economic nexus laws requiring remote sellers to collect sales tax once they exceed a threshold. A dedicated sales tax platform (Avalara, TaxJar) or Shopify Tax handles this automatically for US domestic sales.